Al- and Ga-Doped Graphitic Carbon Nitride as a Temozolomide Nanocarrier Platform: A DFT Study of Adsorption and Interfacial Interactions

Maisha Yousuf; Mohammed Sakib Musa; Arafat Mahamud Bhuiyan; Monir Uzzaman; Md. Ikramul Hossain; Kamol Dey

doi:10.1039/d6na00001k

January 1, 2026Nanoscale AdvancesOpen Access

Al- and Ga-Doped Graphitic Carbon Nitride as a Temozolomide Nanocarrier Platform: A DFT Study of Adsorption and Interfacial Interactions

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Key Points

The aim is to investigate the potential of Al- and Ga-doped graphitic carbon nitride as nanocarriers for temozolomide to enhance its delivery in glioblastoma.
Density Functional Theory (DFT) calculations were performed to evaluate adsorption characteristics.
Interfacial interactions between the nanocarrier and temozolomide were analyzed.
Comparison of drug retention and delivery efficiency of doped systems was conducted.
Doped graphitic carbon nitride showed enhanced adsorption of temozolomide compared to non-doped materials.
Improved interfacial interactions were observed, leading to increased stability of the drug delivery system.

Implication

DFT study explores adsorption and interfacial interactions of TMZ nanocarrier systems, suggesting improved delivery in glioblastoma therapy.

Abstract

The rapid degradation and limited tumor accumulation of temozolomide (TMZ) remain important challenges in glioblastoma chemotherapy, motivating the development of nanocarrier systems that can improve TMZ retention and delivery. This...

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Cite This Study

Yousuf et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d149 https://doi.org/10.1039/d6na00001k

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Al- and Ga-Doped Graphitic Carbon Nitride as a Temozolomide Nanocarrier Platform: A DFT Study of Adsorption and Interfacial Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Al- and Ga-Doped Graphitic Carbon Nitride as a Temozolomide Nanocarrier Platform: A DFT Study of Adsorption and Interfacial Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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