1109-OR: Neuronal Hypothalamic Fibroblast Growth Factor-1 Signaling Is Required for Normal Energy and Glucose Homeostasis and for Protection against Diet-Induced Obesity
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Key Points
The aim was to examine the role of endogenous FGF1 signaling in the mediobasal hypothalamus on energy balance and glucose regulation.
Selective deletion of FGF1 from MBH neurons in adult male FGF1-floxed mice via microinjections.
Physiological assessment using indirect calorimetry metabolic chambers.
Mice were chow-fed initially, followed by a high fat diet (HFD).
Deletion of FGF1 from MBH neurons resulted in increased bodyweight and adiposity (*p<0.05).
Mice exhibited glucose intolerance and disrupted circadian feeding and locomotion patterns.
HFD exacerbated the obesity phenotype, leading to hyperphagia and reduced energy expenditure.
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Implication
Randomized trial reveals that hypothalamic FGF1 is essential for energy and glucose homeostasis, indicating its protective role against obesity.