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June 5, 2026Discover OncologyOpen Access

Identification of hub mRNAs and long non-coding RNAs involved in temozolomide-resistant glioblastoma (brain cancer) cell lines

Mostafa Alamholo Alireza Tarinejad

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Key Points

This research aims to identify crucial genes and molecular mechanisms in glioblastoma cells resistant to temozolomide.
Analyzed RNA-Seq data from glioblastoma cell lines using HISAT2 and edgeR.
Conducted enrichment analysis with KEGG and EnrichR pathways.
Identified hub genes using Cytoscape.
Identified several up-regulated genes including NeuroD4 and ACKR1, and down-regulated genes such as ITGAX and SIGLEC-15.
Top up-regulated lncRNAs included NAV2-AS2, and down-regulated lncRNAs included MIR3142HG.
Validated gene expressions through qRT-PCR corroborated the RNA-Seq findings.

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Implication

Identifies key mRNAs and lncRNAs related to drug resistance in glioblastoma, suggesting targets for personalized treatment.

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Cite This Study

Alamholo et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d25a https://doi.org/10.1007/s12672-026-05243-2

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