What does this research mean for the field?

A newly developed metabolomic risk score for socioeconomic position (SEP-MRS) is significantly associated with an increased risk of incident type 2 diabetes over a 12-year period in the US Hispanic/Latino population. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to develop a metabolomic risk score based on socioeconomic position and assess its link to type 2 diabetes.

June 7, 2026Diabetes

2348-P: Metabolomic Signature of Socioeconomic Position and Incident Type 2 Diabetes in the Hispanic Community Health Study/Study of Latinos

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Type 2 diabetes (n=5097). Intervention: Socioeconomic position metabolomic risk score (SEP-MRS) vs. Lower SEP-MRS (per SD increase). Primary outcome: Incident type 2 diabetes (IRR 1.17, 95% CI 1.07-1.29).

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Key result

Higher socioeconomic metabolomic risk score linked to ~17% greater type 2 diabetes risk per SD.

IRR 1.17
95% CI 1.07-1.29
n=5,097

Why the study?

The link between socioeconomic position and diabetes risk is well documented, but its underlying biological mechanisms remain poorly understood.

Is a socioeconomic position metabolomic risk score associated with incident type 2 diabetes in Hispanic/Latino adults?

Population

5,097 HCHS/SOL participants aged 18-76 years without diabetes at baseline

Comparison

Higher vs lower SEP-MRS

Design

Prospective cohort study

Follow-up

12-year follow-up period

Authors

MBMonica BatalhaAlbert Einstein College of Medicine KPKRISTA M. PERREIRAPrecision Research Institute WTWASSIM TARRAFPrecision Research Institute

Discussion

Member takes

Implication

May identify metabolomic pathways underlying socioeconomic diabetes disparities in Hispanics; hypothesis-generating and requires prospective validation.

Key Points

This research aims to develop a metabolomic risk score based on socioeconomic position and assess its link to type 2 diabetes.
Analyzed data from HCHS/SOL participants aged 18-76 without diabetes at baseline.
Utilized metabolome-wide association analysis to identify metabolites associated with socioeconomic position.
Constructed a weighted metabolomic risk score using LASSO regression and modeled the association with incident T2D using Poisson regression over 12 years.
Identified 115 metabolites associated with lower socioeconomic position, with significant associations in lipid and amino acid modules.
Higher SEP-MRS correlated with increased risk of T2D (IRR = 1.17 [95% CI: 1.07;1.29], per SD).
Lipid, amino acid, and xenobiotic modules showed positive association with T2D, while cofactor and vitamin modules showed an inverse association.

Study Design

Type

Cohort (n=5,097)

Multicenter

Yes

Structured PICO

Is a socioeconomic position metabolomic risk score associated with incident type 2 diabetes in Hispanic/Latino adults?

Population

5,097 Hispanic/Latino adults aged 18-76 years without diabetes at baseline, followed for 12 years.

Exposure

Socioeconomic position metabolomic risk score (SEP-MRS)

Comparator

Lower vs. higher socioeconomic position, and continuous SEP-MRS

Outcome

Incident type 2 diabetes over a 12-year follow-up periodhard clinical

Main Result

Relative Risk: 1.17 (95% CI 1.07–1.29)

A metabolomic risk score reflecting lower socioeconomic position is significantly associated with an increased risk of incident type 2 diabetes in Hispanic/Latino adults.

Cite This Study

Batalha et al. (2026) conducted a cohort in Type 2 diabetes (n=5,097). Socioeconomic position metabolomic risk score (SEP-MRS) vs. Lower SEP-MRS (per SD increase) was evaluated on Incident type 2 diabetes (IRR 1.17, 95% CI 1.07-1.29). Among Hispanic/Latino adults in the US, a 1-SD increase in a socioeconomic position metabolomic risk score was associated with a higher risk of incident type 2 diabetes (IRR 1.17; 95% CI 1.07-1.29).

synapsesocial.com/papers/6a250ce97def13d035e1d270 https://doi.org/10.2337/db26-2348-p

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Implication

May identify metabolomic pathways underlying socioeconomic diabetes disparities in Hispanics; hypothesis-generating and requires prospective validation.

2348-P: Metabolomic Signature of Socioeconomic Position and Incident Type 2 Diabetes in the Hispanic Community Health Study/Study of Latinos

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

2348-P: Metabolomic Signature of Socioeconomic Position and Incident Type 2 Diabetes in the Hispanic Community Health Study/Study of Latinos

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider