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Intramolecular phenoxylative cyclization produces new S,O-heterocycles, expanding α-C(sp3)–H functionalization options.
An intramolecular α-C(sp3)–H phenoxylative cyclization of thioethers is developed using phenols as intramolecular nucleophiles and Selectfluor as a mild oxidant, thereby efficiently constructing seven-membered S,O-heterocyclic scaffolds with high efficiency and excellent functional group tolerance. This phenoxy–Pummerer transformation expands the tool box for α-C(sp3)–H functionalization of thioethers, which provides a new paradigm for incorporating oxidation-sensitive nucleophiles under mild conditions.
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Liu et al. (2026) studied this question.
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