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An asymmetric total synthesis of bromophycoic acid E, which belongs to the class of halogenated meroterpenoid natural products, is presented herein. The key steps in the synthesis are an acid-mediated intramolecular phenol cyclization for the construction of the tetracyclic core and a radical deoxy bromination. This synthesis revealed the absolute configuration of the natural product, confirmed its antimicrobial activity, and laid the groundwork for future structure–activity relationship studies.
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Duvnjak et al. (2026) studied this question.
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