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This is a In Vitro Study study.

Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization

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Enantioselective synthesis achieves total synthesis of psathyrin A in 19 steps, indicating innovative methodologies in radical cyclization.

The total synthesis of (−)-psathyrin A is achieved through enantioselective methods and radical cyclization.
Key steps include a Suzuki–Miyaura coupling and a gold(I)-catalyzed Conia-ene reaction for ring formation.
Radical cyclization builds the tetracyclic carbon framework, completing the complex molecule synthesis.
This synthesis introduces novel strategies for constructing quaternary centers in complex natural products.

Zhao et al. (2025) studied this question.

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Enantioselective synthesis achieves total synthesis of psathyrin A in 19 steps, indicating innovative methodologies in radical cyclization.