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The research aims to achieve the stereocontrolled total synthesis of (+)-penicibilaenes A and B.

January 22, 2026Organic Letters

Total Syntheses of (+)-Penicibilaenes A and B via Enantioselective Desymmetrization

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The research aims to achieve the stereocontrolled total synthesis of (+)-penicibilaenes A and B.
Utilized Pd-catalyzed enantioselective desymmetrization to create chiral intermediates.
Employed ring-closing metathesis to construct the bicyclo[3.3.1]nonane core.
Applied intramolecular nitrile oxide [3 + 2] cycloaddition for assembling the dodecane skeleton.
Successfully synthesized (+)-penicibilaenes A and B through the outlined steps.
Achieved a highly functionalized cyclohexene as a crucial intermediate.
Enabled creation of complex molecular structures with significant stereochemistry.

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Total synthesis reveals new methods for creating complex molecules, showcasing potential applications in pharmaceuticals.

Iwanaga et al. (2026) studied this question.

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