Enantioselective Total Synthesis of (−)‐Euxanmodin B: An Axially Chiral Natural Product with an Anthraquinone–Xanthone Composite Structure

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The first total synthesis of (−)-euxanmodin B is described. An axially chiral, enantiomerically pure biphenyl, available by enzymatic desymmetrization of σ-symmetric biaryl diacetate, was used as the key chiral biaryl building block. Two annulation reactions allowed the construction of the xanthone–anthraquinone composite structure with full stereochemical control.