Why the study?
AF substantially increases the risk of ischemic stroke and systemic embolism, particularly in elderly patients, making it critical to understand real-world patterns of anticoagulation use in this population.
Does older age (76-89 years) increase the risk of anticoagulation underutilization compared to younger age (50-75 years) in patients with nonvalvular atrial fibrillation?
Population
6,386 patients with nonvalvular AF between 2021 and 2024
Comparison
Patients 76–89 years old vs 50–75 years old
Design
Retrospective, single-center chart review study
Key result
Patients aged 76-89 years had significantly higher odds of anticoagulation underutilization compared to those aged 50-75 years (OR 4.547; 95% CI 3.827-5.403).
Authors
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Suggests age-related anticoagulation gaps in nonvalvular AF; hypothesis-generating for targeted interventions in the elderly.
Cohort (n=6,386)
No
Does older age (76-89 years) increase the risk of anticoagulation underutilization compared to younger age (50-75 years) in patients with nonvalvular atrial fibrillation?
Odds Ratio: 4.547 (95% CI 3.827–5.403)
Elderly patients (76-89 years) with nonvalvular atrial fibrillation are significantly more likely to experience anticoagulation underutilization compared to younger patients (50-75 years), highlighting the challenge of balancing stroke and bleeding risks.
Jia et al. (2026) conducted a cohort in Nonvalvular atrial fibrillation (n=6,386). Age 76-89 years vs. Age 50-75 years was evaluated on Anticoagulation underutilization (CHA2DS2-VASc > 2, ORBIT ≥ 3, without AC) (OR 4.547, 95% CI 3.827-5.403). Patients aged 76-89 years had significantly higher odds of anticoagulation underutilization compared to those aged 50-75 years (OR 4.547; 95% CI 3.827-5.403).