The effect of two diets on the growth, reproduction and ultimate size of guinea-pigs

The guinea-pig first achieved fame as an experimental animal in the eighteenth century, when Lavoisier used it for his fundamental experiments on respiration (Lavoisier & La Place, 1784; Seguin & Lavoisier, 1793). It did not, however, begin to make nutritional history till the twentieth century, when Holst & Frolich (1go7), in trying to give it beriberi, found that it developed scurvy instead; they thus opened up scurvy to an experimental attack. The guinea-pig, however, has never approached the rat in popularity for general nutritional work, and this is unfortunate, in that the guinea-pig has many points of resemblance to man in its rate of growth and reproductive performance