Why the study?
Does misoprostol prevent and manage upper gastrointestinal ulcers associated with NSAID use?
Does misoprostol prevent and manage upper gastrointestinal ulcers associated with NSAID use?
This article reviews the clinical use of misoprostol for preventing and treating NSAID-induced gastroduodenal ulceration.
Answers are grounded in this paper and cite their sources.
May support misoprostol for NSAID ulcers; extends literature but leaves open need for updated RCTs.
MISOPROSTOL was the first analogue of prostaglandin E1 to be commercially available. It was developed after prostaglandins of the E series had been found to inhibit the secretion of acid and prevent gastric injury caused by various substances, with the hope that it would be useful for the prevention and treatment of gastrointestinal ulceration. The aim of this article is to review the use of the drug in clinical practice, with critical appraisal of its role in the prevention and management of upper gastrointestinal ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs). In the United Kingdom, misoprostol . . .
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Wood et al. (1992) studied this question.
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