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Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H2O2-responsive MnO2 nanosheets anchored with upconversion nanoprobes. They react with acidic H2O2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.
Fan et al. (Mon,) studied this question.