Why the study?
The cohort was established to investigate associations between parental periconceptional nutritional factors and congenital heart disease, as well as child growth, development, and paediatric diseases.
The Shanghai Preconception Cohort is a large prospective study designed to evaluate the impact of periconceptional parental nutritional factors on the risk of congenital heart disease and other pediatric outcomes.
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Suboptimal periconceptional RBC folate status remains prevalent; hypothesis-generating for CHD risk associations pending full cohort follow-up.
Wang et al. (2019) studied this question.
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