Novel synthesis demonstrates effective production of (2S,3R)-β-methyltryptophans, indicating potential for diverse therapeutic applications.
The surging demand for novel tryptophan analogues across small-molecule, bioactive peptide, and conjugate therapeutic modalities underscores an unmet synthetic need for efficient access to (2S,3R)-β-methyltryptophans. Herein, we describe a practical and stereospecific synthesis of (2S,3R)-β-methyltryptophans that offers broad functional group compatibility and structural diversity.
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Ma et al. (2026) studied this question.
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