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This research aims to develop a one-pot biocatalytic method for synthesizing 5-MeO-tryptamine efficiently.

June 11, 2026Open Access

Highly Efficient One-Pot Bi-Enzymatic Cascade to 5-MeO-Tryptamine

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Randomized trial demonstrates efficient synthesis of 5-MeO-tryptamine using enzymes, implying a greener production method.

This research aims to develop a one-pot biocatalytic method for synthesizing 5-MeO-tryptamine efficiently.
Developed a one-pot tandem two-enzyme cascade using EcTnaA and RgnTDC.
Operated under mild aqueous conditions with solid suspensions of 5-MeO-indole.
Achievements included yields up to 95% in 23 hours and STY of 2.1 g L⁻¹ h⁻¹.
Achieved synthesis yields up to 95% with a 23-hour reaction time.
Demonstrated a yield of 88% in 4 hours with solid suspensions of 5-MeO-indole.
Showed a 35-fold increase in space-time yield compared to previous methods.

Rassati et al. (2025) studied this question.

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