What question did this study set out to answer?

To determine if genetically predicted blood metabolite features have causal effects on myocardial infarction.

June 8, 2026MedicineOpen Access

Causal effects between blood metabolites and myocardial infarction: A 2-sample Mendelian randomization study

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Randomized trial evaluates causal link between blood metabolites and myocardial infarction, suggesting new metabolic pathways.

To determine if genetically predicted blood metabolite features have causal effects on myocardial infarction.
Conducted a 2-sample Mendelian randomization study using genetic variants as instruments.
Analyzed data from 452 blood metabolite features and MI summary statistics from two large GWAS.
Applied inverse-variance weighted method, complemented by various sensitivity analyses including MR-Egger and funnel plots.
In FinnGen, 12 annotated metabolite features associated with lower MI risk; 8 associated with higher MI risk.
In the IEU Open GWAS, 10 features were protective and 7 were risk-associated.
Five metabolite features showed consistent associations across both datasets, indicating robust findings.

Fu et al. (2026) studied this question.

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