Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay

Q: What does this research mean for the field?

Children with global developmental delay exhibit significantly reduced iron deposition in deep gray matter nuclei, which correlates with poorer motor and social developmental scores. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tianyu Li; Xin Zhao; Liang Zhou; Lin Lu; Meiying Cheng; Honglei Shang; Xueyan Liu; Ning Wang; 玄德聖; Junjie Liao; Xiang Yue; Xi Zhang

doi:10.1007/s00247-026-06669-0

June 6, 2026Pediatric RadiologyOpen Access

Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study aimed to examine brain iron deposition in deep gray matter nuclei in children with global developmental delay to improve early diagnosis and intervention.
Enrolled 71 children with global developmental delay and 31 typically developing controls.
Used quantitative susceptibility mapping data from a 3.0-T MRI scanner and analyzed using MATLAB.
Conducted between-group comparisons and correlation analyses between susceptibility values and developmental scores.
Children with global developmental delay showed significantly lower magnetic susceptibility in the bilateral thalamus, substantia nigra, and dentate nucleus (all P<0.05).
Susceptibility values of the bilateral dentate nucleus correlated positively with gross motor and personal-social skills (P<0.001 to P=0.027).
ROC analysis indicated the right dentate nucleus had an area under the curve of 0.83, suggesting strong diagnostic potential.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Investigates brain iron deposition patterns in children with global developmental delay, indicating potential biomarkers for early diagnosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a265ccbad53cfb9357c60c3 https://doi.org/10.1007/s00247-026-06669-0

View Full Paper

Ask AI

Bookmark

Share

Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Quantitative susceptibility mapping reveals abnormal iron reduction in deep gray matter of children with global developmental delay

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading