Key result
Moderate-to-severe renal dysfunction is linked to adverse in-hospital outcomes in NSTEMI and unstable angina.
Why the study?
While long-term outcomes are poor in acute myocardial infarction patients with renal dysfunction, less is known about short-term outcomes in acute coronary syndrome.
Does moderate to severe renal dysfunction predict adverse in-hospital outcomes in patients with acute coronary syndrome?
Observational (n=70)
Does moderate to severe renal dysfunction predict adverse in-hospital outcomes in patients with acute coronary syndrome?
Moderate to severe renal impairment is a predictor of in-hospital morbidity and mortality in patients with NSTEMI and unstable angina.
Background: The outcome is poor in patients with acute myocardial infarction (MI) who have renal dysfunction in long-term follow-up. Less is known about the outcome of acute MI in the short term. Objectives: We aimed to evaluate the outcome of patients with acute coronary syndrome (ACS) across varying degrees of renal dysfunction. Materials and methods: Seventy patients presenting with ACS, including ST-segment elevation MI (STEMI), non-ST-segment elevation MI (NSTEMI), and unstable angina (UA), were enrolled in this prospective observational study. Sociodemographic and clinical characteristics and in-hospital outcomes were compared for patients according to glomerular filtration rate (GFR). Results: Patients with moderate to severe renal dysfunction were elderly females and associated with more comorbidities and adverse outcomes if compared with patients who had normal to mild renal dysfunction. When the enrolled patients were divided into two groups, STEMI and NSTEMI/UA, a significant difference was observed between these two groups. There was no significant association between STEMI with the occurrence of adverse outcomes and the presence of moderate to severe renal dysfunction. On the other hand, there is a significant association with the occurrence of adverse outcomes among patients in the NSTEMI/UA group. Conclusion: Moderate to severe renal impairment is a predictor of in-hospital morbidity and mortality in ACS.
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Al-Sharea et al. (2025) conducted an observational in Acute Coronary Syndrome (n=70). Moderate to severe renal dysfunction vs. Normal to mild renal dysfunction was evaluated on In-hospital adverse outcomes. Moderate to severe renal dysfunction was significantly associated with adverse in-hospital outcomes in patients with NSTEMI and unstable angina, though specific event rates were not reported.
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