Key result
End-stage renal disease in patients with acute MI was associated with significantly higher postdischarge mortality compared to those without renal disease (HR 5.4; 95% CI 3.0-9.7; P<0.001).
Why the study?
Does renal dysfunction increase the risk of mortality in patients with acute myocardial infarction?
Population
3106 patients admitted with acute myocardial infarction, stratified by renal function.
Comparison
Varying levels of renal dysfunction vs No renal disease
Design
Cohort
Authors
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ESRD signals high post-MI mortality warranting vigilance; leaves open whether targeted interventions improve outcomes.
Cohort (n=3,106)
No
Does renal dysfunction increase the risk of mortality in patients with acute myocardial infarction?
Hazard Ratio: 5.4 (95% CI 3–9.7)
p-value: p=<0.001
Renal dysfunction is a strong, graded predictor of increased in-hospital and postdischarge mortality in patients with acute myocardial infarction, who also receive less aggressive reperfusion and adjunctive therapies.
Wright et al. (2002) conducted a cohort in Acute myocardial infarction and renal dysfunction (n=3,106). End-stage renal disease vs. No renal disease was evaluated on Postdischarge death (HR 5.4, 95% CI 3.0-9.7, p=<0.001). End-stage renal disease in patients with acute MI was associated with significantly higher postdischarge mortality compared to those without renal disease (HR 5.4; 95% CI 3.0-9.7; P<0.001).
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