Key result
Chronic renal insufficiency linked to ~230% higher 30-day mortality in AMI, driven partly by undertreatment.
Why the study?
Patients with AMI and chronic renal insufficiency are at high risk of complications and death, and physicians may underprescribe life-saving medications in this population.
Does chronic renal insufficiency increase the risk of complications and death in patients with acute myocardial infarction?
Population
1,683 consecutive AMI patients categorized by renal function
Comparison
Patients with normal renal function vs mild to moderate CRI vs severe CRI
Design
Cohort study
Follow-up
30 days
Authors
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Underutilization of AMI therapies in CRI patients was linked to higher 30-day mortality; leaves open whether optimized prescribing improves outcomes in this observational cohort.
Cohort (n=1,683)
Does chronic renal insufficiency increase the risk of complications and death in patients with acute myocardial infarction?
Odds Ratio: 3.3 (95% CI 2–4.8)
Patients with acute myocardial infarction and chronic renal insufficiency have significantly higher 30-day mortality, which is exacerbated by the underutilization of standard evidence-based therapies such as beta-blockers.
Tessone et al. (2006) conducted a cohort in Acute myocardial infarction (AMI) and chronic renal insufficiency (CRI) (n=1,683). Chronic renal insufficiency vs. Normal renal function (<1.5 mg/dl) was evaluated on Death within 30 days (OR 3.3, 95% CI 2.0-4.8). Chronic renal insufficiency in patients with acute myocardial infarction was associated with increased 30-day mortality (OR 3.3; 95% CI 2.0-4.8), partly driven by underutilization of standard care.
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