Key result
Transcription factors regulate fetal gene reprogramming, energy metabolism, apoptosis, and autophagy in cardiomyocytes, playing a critical role in the development and prognosis of cardiac remodeling.
Why the study?
The complete mechanism of cardiac remodeling remains unrecognized, hindering effective treatment and drug development.
Answers are grounded in this paper and cite their sources.
Transcription factors play a critical role in the development and prognosis of cardiac remodeling, highlighting their potential as therapeutic targets for heart failure.
To compensate increasing workload, heart must work harder with structural changes, indicated by increasing size and changing shape, causing cardiac remodeling. However, pathological and unlimited compensated cardiac remodeling will ultimately lead to decompensation and heart failure. In the past decade, numerous studies have explored many signaling pathways involved in cardiac remodeling, but the complete mechanism of cardiac remodeling is still unrecognized, which hinders effective treatment and drug development. As gene transcriptional regulators, transcription factors control multiple cellular activities and play a critical role in cardiac remodeling. This review summarizes the regulation of fetal gene reprogramming, energy metabolism, apoptosis, autophagy in cardiomyocytes and myofibroblast activation of cardiac fibroblasts by transcription factors, with an emphasis on their potential roles in the development and prognosis of cardiac remodeling.
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Hong et al. (2022) conducted a review in Cardiac Remodeling. Transcription factors was evaluated. Transcription factors regulate fetal gene reprogramming, energy metabolism, apoptosis, and autophagy in cardiomyocytes, playing a critical role in the development and prognosis of cardiac remodeling.
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