Key result
A multi-scale electromechanically coupled finite element method based model was developed to simulate the electromechanics of human induced pluripotent stem cell-derived cardiomyocytes.
Why the study?
Cultivated hiPSC-CMs serve as an in vitro model for native cardiomyocytes, and CellDrum mechanical measurements can be extended by simulations.
The study presents a multi-scale electromechanically coupled finite element model to simulate and measure the electromechanics of human induced pluripotent stem cell-derived cardiac tissue.
Answers are grounded in this paper and cite their sources.
May aid preclinical hiPSC-CM modeling; leaves open validation for pharmacological or clinical translation.
Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) have become a promising in vitro model for human native cardiomyocytes. Cultivated tissue samples beat autonomously and can be used for basic and pharmacological research. For mechanical measurements of these tissue samples, the CellDrum technology has been developed. Measurements are extended by simulations with a multi‐scale electromechanically coupled finite element method based model. This model can be parameterized and validated experimentally. The paper describes the model, its workflow, and preliminary simulations to study the effect of fibroblasts and a selected cardiac drug on the electromechanics of hiPSC‐CMs.
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Jung et al. (2019) studied this question. Multi-scale electromechanically coupled finite element method based model was evaluated. A multi-scale electromechanically coupled finite element method based model was developed to simulate the electromechanics of human induced pluripotent stem cell-derived cardiomyocytes.
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