Key result
Non-obstructive hypertrophic cardiomyopathy was associated with significantly decreased global work efficiency (83.96% vs. 95.26%) and increased global waste work compared to healthy controls.
Why the study?
To evaluate myocardial work using speckle tracking echocardiography in patients with non-obstructive hypertrophic cardiomyopathy.
Does myocardial work assessed by speckle tracking echocardiography differ between patients with non-obstructive hypertrophic cardiomyopathy and normal controls?
Case-Control (n=100)
No
Does myocardial work assessed by speckle tracking echocardiography differ between patients with non-obstructive hypertrophic cardiomyopathy and normal controls?
Absolute Event Rate: 83.96% vs 95.26%
p-value: p=<0.05
Myocardial work parameters derived from speckle tracking echocardiography are significantly altered in patients with non-obstructive HCM and may serve as early indicators of left ventricular dysfunction.
Altered myocardial work may signal early LV impairment in non-obstructive HCM; leaves open prognostic value and need for prospective validation.
BACKGROUND: To evaluate myocardial work using speckle tracking echocardiography in patients with non-obstructive hypertrophic cardiomyopathy (HCM). METHODS: Fifty patients with HCM and 50 normal controls were included. Left ventricular ejection fraction (LVEF) was quantified using the bi-plane Simpson's method. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE), were derived from the 2D strain-pressure loop. RESULTS: ) and systolic blood pressure (121.81 ± 16.50 vs. 115.30 ± 11.01 mmHg) (P < 0.05). The mean LVEF in patients was 51%, with 54% of patients had LVEF ≤ 50%. Compared to controls, GWI (946.42 ± 360.64 vs. 1639.72 ± 204.56 mmHg%), GCW (1176.94 ± 373.23 vs. 1960.16 ± 255.72 mmHg%), and GWE (83.96 ± 7.68 vs. 95.26 ± 1.98%) were significantly decreased, while GWW (158.17 ± 82.47 vs. 79.12 ± 40.26 mmHg%) was significantly increased (P < 0.05) in the patient group. In patients, GWE showed a trend of positive correlation with LVEF (r = 0.276, P = 0.06), while GWW had a trend of negative correlation with LVEF (r = - 0.241, P = 0.09). No correlation between myocardial work and LV diastolic function or QRS duration was observed. Maximal wall thickness significantly correlated with all the myocardial work parameters. CONCLUSIONS: Assessing myocardial work adds useful information of LV function in patients with non-obstructive HCM.
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Yang et al. (2022) conducted a case-control in Non-obstructive hypertrophic cardiomyopathy (n=100). Non-obstructive hypertrophic cardiomyopathy vs. Healthy controls was evaluated on Global work efficiency (GWE) (p=<0.05). Non-obstructive hypertrophic cardiomyopathy was associated with significantly decreased global work efficiency (83.96% vs. 95.26%) and increased global waste work compared to healthy controls.
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