June 9, 2026Journal of the American College of Cardiology274 citations
View Full PaperTranslation of Human-Induced Pluripotent Stem Cells
Key Points
- This research aims to explore the implications of induced pluripotent stem cell technology in various biomedical fields.
- Comprehensive review of recent advancements in iPSC technology
- Examination of applications in basic, clinical, and population health
- Discussion of ethical considerations associated with traditional stem cell sources
- iPSCs offer advantages over human embryonic stem cells in therapeutic applications.
- Three major applications of iPSCs have been identified: disease modeling, regenerative therapy, and drug discovery.
- The use of iPSCs is rapidly expanding due to their versatility and ethical benefits.
Abstract
The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has completely altered the outlook of biomedical research. Human induced pluripotent stem cells (iPSCs) provide a new source of therapeutic cells free from the ethical issues or immune barriers of human embryonic stem cells. iPSCs also confer considerable advantages over conventional methods of studying human diseases. Since its advent, iPSC technology has expanded, with 3 major applications: disease modeling; regenerative therapy; and drug discovery. Here we discuss, in a comprehensive manner, the recent advances in iPSC technology in relation to basic, clinical, and population health.