What does this research mean for the field?

Berbamine effectively inhibits Japanese encephalitis virus (JEV) infection in vitro and in vivo by blocking TRPML channels, which disrupts the endolysosomal trafficking of the viral entry receptor LDLR. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the antiviral effects of berbamine on Japanese encephalitis virus (JEV) infection and its underlying mechanisms.

January 1, 2021Emerging Microbes & InfectionsOpen Access

Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR)

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This research aims to investigate the antiviral effects of berbamine on Japanese encephalitis virus (JEV) infection and its underlying mechanisms.
Identified LDLR as a host factor for JEV entry.
Examined the effect of berbamine on LDLR trafficking and secretion via extracellular vesicles.
Evaluated the protective effects of berbamine on mice infected with JEV.
Berbamine significantly reduced LDLR levels at the plasma membrane, decreasing JEV entry.
Increased LDLR secretion via extracellular vesicles was observed after berbamine treatment.
Berbamine protected mice from lethal JEV infection.

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Implication

Randomized trial shows berbamine inhibits JEV infection in mice, suggesting a potential antiviral treatment.

Cite This Study

Huang et al. (2021) studied this question.

synapsesocial.com/papers/6a278ce7e6dca081da41a6df https://doi.org/10.1080/22221751.2021.1941276

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Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR)

Key Points

Discussion

Implication

Cite This Study

Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR)

Key Points

Discussion

Implication

Cite This Study

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