Key result
High TG/HDL-C ratio linked to ~196% greater odds of CAVD.
Why the study?
The TG/HDL-C ratio is an emerging marker of cardiovascular risk, but its potential to predict the development of calcific aortic valve disease remained to be investigated.
Is an elevated TG/HDL-C ratio associated with the presence of calcific aortic valve disease?
Case-Control (n=400)
No
Is an elevated TG/HDL-C ratio associated with the presence of calcific aortic valve disease?
Answers are grounded in this paper and cite their sources.
An elevated TG/HDL-C ratio is independently associated with the presence of calcific aortic valve disease and may serve as a simple, accessible biomarker for risk assessment.
BACKGROUND: The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics. METHODS: Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed. Clinical parameters were compared between groups, and logistic regression was utilized to explore the association of the TG/HDL-C ratio with CAVD. The diagnostic performance of the TG/HDL-C ratio was assessed using receiver operating characteristic (ROC) curves. RESULTS: The TG/HDL-C ratio was notably higher in the CAVD group than in the controls (Z = -7.98, P < 0.001). Multivariable logistic regression analysis indicated that the TG/HDL-C ratio is an independent predictor of CAVD after adjusting for confounders including gender. The ROC curve analysis revealed that the TG/HDL-C ratio achieved a sensitivity of 80.5%, a specificity of 59.5%, and an area under the curve (AUC) of 0.731 (P < 0.001), confirming its efficacy in predicting CAVD. CONCLUSIONS: High TG/HDL-C ratio was significantly associated with the occurrence of CAVD, and the TG/HDL-C ratio could be used as a potential diagnostic tool and risk assessment indicator for CAVD. CLINICAL TRIAL NUMBER: Not applicable.
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Chen et al. (2024) conducted a case-control in Calcific aortic valve disease (n=400). High TG/HDL-C ratio (≥ 1.18) vs. Low TG/HDL-C ratio (< 1.18) was evaluated on Presence of calcific aortic valve disease (OR 2.96, 95% CI 1.71 to 5.72, p=< 0.001). A high TG/HDL-C ratio (≥ 1.18) was independently associated with the occurrence of calcific aortic valve disease (OR 2.96) and achieved a diagnostic AUC of 0.731.
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