Evolution in the test tube: With the help of the error-prone polymerase chain reaction as a method for random mutagenesis, an efficient gene-expression system, and a screening test for the rapid identification of enantioselective catalysts, it is possible to increase sequentially the ee value of an unselective lipase-catalyzed ester hydrolysis (see picture on the right).
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Reetz et al. (1997) studied this question.
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