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June 9, 2026Synthetic Communications

Copper-catalyzed synthesis of heterocycles via single and two-electron pathways

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Authors

TPTrapti PorwalRKRajnish KumarSTShristi Tripathi

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Overview

Review highlights diverse copper-catalyzed synthesis pathways for heterocycles, suggesting advancements for sustainable methods.

Key Points

  • The aim is to review copper-catalyzed methods for synthesizing heterocycles and explore their mechanistic pathways.
  • Comprehensive survey of literature from 2015 to 2024 on copper-catalyzed heterocycles synthesis.
  • Examination of mechanistic diversity, including single-electron transfer and two-electron pathways.
  • Analysis of synthesis methods employing C–H functionalization, multicomponent reactions, and green chemistry principles.
  • Highlighted key advances in microwave-assisted and flow-chemistry protocols for heterocycle synthesis.
  • Identified challenges in current synthesis methods and proposed strategies for improvement.
  • Discussed future directions, including integrating photoredox and electrochemical techniques for scalability.

Cite This Study

Porwal et al. (2026) studied this question.

synapsesocial.com/papers/6a27ad4ea963992e1626788fhttps://doi.org/10.1080/00397911.2026.2682562
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