ABSTRACT Thiazole and its derivatives represent an important class among heterocyclic moieties exhibiting a wide range of biological and pharmacological activities. In recent years, copper catalysis has emerged as an efficient and sustainable strategy for the construction of thiazole scaffolds due to its cost‐effectiveness, versatility and environmental compatibility. This review comprehensively summarizes the progress made from 2009 to April, 2026 in the copper‐catalyzed synthesis of thiazole derivatives, focusing on various synthetic methodologies, optimal reaction conditions, and generality and mechanistic pathways. Special attention is given to the catalytic role of copper species in promoting key bond‐forming transformations such as C–C, C─N, and C─S couplings. The pros and/or cons, key features and potential challenges associated with these methods are discussed well. In addition, mechanistic insights are elaborated to provide a deeper understanding of copper catalyst's role in the construction of various thiazoles. Overall, this review aims to provide an updated perspective on copper‐catalyzed strategies for thiazole synthesis and serves as a valuable guide for developing efficient, novel, and sustainable methodologies in the field of heterocyclic and medicinal chemistry.
Suresh et al. (Mon,) studied this question.