Abstract Background Fatal drug-related harms have risen across high-income countries over the past decade, yet national surveillance systems differ substantially in case definitions, reporting timeliness, and indicator coverage. These differences make it difficult to determine whether observed cross-national differences reflect epidemiological divergence or heterogeneous measurement. Methods To address this, we compared public surveillance indicators of fatal drug-related harm across the USA, Canada, England and Wales, and European countries reporting to the European Union Drugs Agency (2015–23), using three domains: drug-supply toxicity, surveillance latency, and treatment-system integration. Results Fatal drug-harm indicators suggested divergent trajectories: the USA experienced rapid mortality escalation through 2022 followed by a modest decline, while England and Wales reported continued increases in registration-based deaths. In Canada, deaths involving three or more substances increased from 20% in 2018 to 42% in 2023, with opioid–stimulant combinations accounting for ~60% of deaths by 2023. European estimates remained provisional due to incomplete national reporting. Differences between occurrence-based and registration-based surveillance influenced the apparent timing of trends. Continuity of opioid agonist treatment across incarceration transitions emerged as a measurable treatment-integration signal. Conclusions High-income settings appear to follow distinct fatal drug-harm trajectories shaped by drug-supply toxicity, surveillance architecture, and treatment-system integration. A structured multi-domain framework can help distinguish epidemiological divergence from variation caused by measurement and reporting. It can also guide improvements in timely surveillance, treatment-continuity monitoring, and cross-jurisdictional learning.
Albert et al. (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: