What question did this study set out to answer?

To analyze trends in accidental poisoning deaths related to drugs and substances in the US from 1999 to 2023.

May 3, 2026

Trends in accidental poisoning and exposure to noxious substances involving drugs, medicaments, and biological substances-related deaths: A nationwide US analysis, 1999 to 2023.

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Nationwide analysis reveals rising drug-related accidental poisoning deaths, suggesting urgent intervention needs.

To analyze trends in accidental poisoning deaths related to drugs and substances in the US from 1999 to 2023.
Analyzed CDC WONDER Multiple Cause of Death database mortality data from 1999 to 2023.
Extracted age-adjusted mortality rates per 100,000 individuals.
Employed Joinpoint regression to evaluate demographic and geographic patterns.
Age-adjusted mortality rates increased from 4.8 to 30.8 per 100,000 individuals from 1999 to 2023 (P < .05).
Crude mortality rate for men reached 45.3 per million compared to 18.2 for women in 2022.
The most significant rise in mortality occurred between 2019-2020, particularly in middle-aged adults.

Lodh et al. (2026) studied this question.

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