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Investigates IL-25's role in eosinophil-associated inflammation in infected mice, suggesting significant implications for disease understanding.
This study aimed to investigate the role of interleukin (IL)‐25 in the pathogenesis of angiostrongylosis. We used ICR mice as non‐permissive hosts, divided them into groups and experimentally infected them with infective larvae of the Angiostrongylus cantonensis . Two groups of infected mice were injected intraperitoneally with either mouse IL‐25 or an anti‐IL‐25 monoclonal antibody (mAb) at 3 days post‐infection (dpi), followed by booster injections at the same dose every 5 days. Serum samples and brain tissues were collected weekly from each group for immunological and pathological examinations. The IL‐25‐treated group exhibited significant increases in eosinophil percentages and levels of immunoglobulin E (IgE), as well as in the levels of IL‐5 and IL‐13. The severity of eosinophilic meningitis was exacerbated in the IL‐25‐treated group 21 dpi. These results suggest that IL‐25 may enhance eosinophil‐associated inflammation in mice infected with A. cantonensis .
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Chuang et al. (2026) studied this question.
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