Demonstrates diastereoselective synthesis of polyfluorinated allylsilanes, indicating efficient defluorosilylation approach.
Comprehensive Summary A highly diastereoselective copper‐catalyzed defluorosilylation of pentafluoroethyl alkenes is described. In the presence of CuCN/PCy 3 catalyst, polyfluorinated allylsilanes containing an sp 2 ‐carbon connected to F and CF 3 can be synthesized with E ‐alkene geometry. Without the ligand, the Z ‐alkenes are obtained as major products. Moreover, a one‐pot defluorosilylation/protodesilylation sequence affords the hydrodefluorination product, which can undergo another round of defluorosilylation to generate trifluoromethylated allylsilanes as Z ‐alkenes.
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Zong et al. (2026) studied this question.
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