SN2′ Defluorinative Allylation of Trifluoromethylalkenes with Allylsilanes

This is the authors' abstract. We don't add key points for this paper.

An SN2′ defluorinative allylation of trifluoromethylalkenes with readily available allylsilanes to access homoallyl gem-difluoroalkenes is reported. The reaction is triggered by a catalytic amount of TBAF, with the extruded fluoride in the reaction serving as a sustainable activator for organosilanes. The high efficiency, good functional group tolerance, and mild reaction conditions underline the potential of this method in synthetic chemistry.