A case series of adenomyomatosis of the gallbladder: is it a benign condition?

Adenomyomatosis of the gall bladder is a common benign condition characterised by muscular hypertrophy and Rokitansky-Aschoff sinus formation. We describe four cases of adenomyomatosis with associated neoplastic change, supporting the concept that adenomyomatosis may provide a permissive background for stepwise carcinogenesis, particularly in the setting of chronic inflammation.