Predictors of Long‐Term Kidney Transplant Survival: A Scoping Review

Background and Aims Long‐term kidney transplant survival is a critical challenge in nephrology, which might be influenced by a myriad of recipient, donor, and post‐transplant factors. Despite advancements in medical care, some issues, like transplant rejection and comorbidities, continue to hinder progress. This scoping review aimed to identify predictors of long‐term kidney transplant survival. Methods Following Arksey and O'Malley's framework, this scoping review analyzed studies published between 2014 and 2025 across seven databases. Studies addressing recipient‐, donor‐, and post‐transplant factors as predictors of long‐term kidney transplant survival were included. The findings were categorized by timeframes and predicting factors, and finally, synthesized descriptively. Results Overall, 37 studies were included. Key predictors of long‐term survival included recipient‐related factors such as age, BMI, comorbidities, and serum creatinine levels. Donor‐related factors like age, HLA mismatches, and kidney quality also emerged as significant contributors. Post‐transplant factors, including acute rejection episodes, use of immunosuppressive drugs, and hospital readmissions, were strongly associated with graft outcomes. Conclusion This review highlighted the multifaceted predictors of long‐term kidney transplant survival, emphasizing the need for personalized management strategies. Tailored interventions targeting high‐risk patients and enhanced donor selection protocols are vital for improving outcomes. Future research should focus on examining predictive algorithms to predict transplant survival.