Non-invasive predictors of prognosis of Asian patients with histopathologically-confirmed lean nonalcoholic fatty liver disease

November 4, 2020BMC GastroenterologyOpen Access

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Key Points

The study aims to identify non-invasive predictors of prognosis in Asian patients with lean nonalcoholic fatty liver disease.
Retrospective analysis of 446 Japanese patients with histopathologically-confirmed NAFLD.
Follow-up for liver events, cardiovascular events, type 2 diabetes mellitus, and non-liver malignancies for a median of 4.6 years.
Identification of predictors for severe fibrosis and mortality in lean NAFLD patients.
Glycolipid metabolic markers, liver function tests, and NAFLD fibrosis score were significantly lower in lean NAFLD patients.
NFS ≥ - 1.455 identified as a significant independent predictor of severe fibrosis.
No significant difference in overall survival between lean and non-lean NAFLD patients.

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Retrospective study finds predictors of severe fibrosis and survival in lean NAFLD, indicating need for monitoring.

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Iritani et al. (2020) studied this question.

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