Construction of Nitrogen‐Containing Heterocycles by CH Bond Functionalization

Abstract Bringing synthesis into the 21st century! How can nitrogen heterocycles be synthesized today? An overview of modern methods for nitrogen‐heterocycle formation is given. Chemists can now use readily available materials combined with CH bond functionalization to prepare common nitrogen heterocycles. magnified image Nitrogen heterocycles are abundant in natural products and pharmaceuticals. An emerging interest among synthetic chemists is to use CH functionalization to construct the nitrogen‐containing core of these heterocycles. The following article will provide a brief overview of this concept with respect to the type of CH bond functionalized.