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This case aims to describe a novel condition characterized by complete gamma globulin absence and its clinical implications.

June 1, 1952PEDIATRICS

Agammaglobulinemia

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Case report describes agammaglobulinemia leading to recurrent pneumococcal sepsis, suggesting antibody synthesis alteration.

This case aims to describe a novel condition characterized by complete gamma globulin absence and its clinical implications.
Case report of an 8-year-old male with recurrent pneumococcal sepsis and absence of gamma globulin in serum.
Electrophoretic analysis used to confirm the absence of gamma globulin and monitor subsequent treatment response.
Subcutaneous administration of concentrated immune human serum globulin and regular monthly treatments were conducted.
The patient experienced 19 episodes of pneumococcal sepsis over four years before treatment, with various pneumococcus types isolated.
After treatment with human globulin (3.2 gm gamma globulin), the patient was free of pneumococcal sepsis for over a year.
Electrophoretic analysis confirmed the transient return of gamma globulin in serum following treatment.

Ogden C. Bruton (1952) studied this question.

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