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This study aims to evaluate the diagnostic accuracy of cervical cytology in HPV-independent cervical cancers compared to HPV-associated cases.

Diagnostic performance of cervical cytology in HPV-independent cervical cancer: a comparative analysis with HPV-associated cases

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Randomized trial evaluates cervical cytology accuracy in HPV-independent cancers, suggesting tailored screening is needed.

This study aims to evaluate the diagnostic accuracy of cervical cytology in HPV-independent cervical cancers compared to HPV-associated cases.
Retrospective review of 515 cervical cancer patients diagnosed from 2000 to 2021.
Categorization of patients into HPV-associated (n=439) and HPV-independent (n=76) groups.
Multivariable logistic regression analyses and Kaplan-Meier survival analysis were performed.
HPV-independent cancers had a higher false-negative rate of 39.5% compared to 18.0% in HPV-associated cancers (p<0.001).
High-grade cytological abnormalities were seen in 52.6% of HPV-independent compared to 69.2% of HPV-associated cases.
Patients with HPV-independent cancers demonstrated significantly worse progression-free and overall survival (p<0.001).

Chang et al. (2026) studied this question.

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