Retrospective cohort study reveals diagnostic challenges and outcomes in women with primary ovarian lymphoma, suggesting the importance of timely treatment.
Primary ovarian lymphoma (POL) is rare and often presents as an adnexal mass, creating diagnostic and management challenges. We performed a retrospective cohort study of 13 women diagnosed with POL between January 2018 and December 2023. Median age was 44 years (range 13-69), with 69.2% being premenopausal. LDH was elevated in 9/13 (69.2%) and CA-125 in 8/10 (80.0%) while CEA and CA19-9 were negative. Histology was heterogeneous: diffuse large B-cell lymphoma (DLBCL, 46.2%), extranodal NK/T-cell lymphoma (23.1%), Burkitt lymphoma (15.4%), marginal zone lymphoma (7.7%), and follicular lymphoma (7.7%). Median follow-up was 28 months (range 0.5-84). Three deaths occurred, all in patients without timely systemic therapy. Estimated 5-year OS was approximately 76.9% (95% CI, 57.1%-100%). In this contemporary POL series, clinicopathologic heterogeneity was prominent, and laboratory profiles frequently overlapped with ovarian malignancy work-up. Outcomes may be favorable among patients receiving timely, subtype-appropriate systemic treatment.
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Shan et al. (2026) studied this question.
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