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June 10, 2026Aging & Mental Health

Associations between residential environments and the risk of incident Alzheimer’s disease and mild cognitive impairment: a 13-year prospective cohort study with 426,220 participants

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Authors

XLXinjie LiuShandong UniversityYZYu ZhangSouth China Agricultural UniversityXZXi ZhangGeneral Cardiology

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Implication

Cohort study finds that higher green and natural spaces lower Alzheimer’s and cognitive impairment risks, suggesting potential health benefits.

Key Points

  • The study aims to investigate the relationship between residential environments and the incidence of Alzheimer's disease and mild cognitive impairment.
  • Followed 426,220 dementia-free participants from the UK Biobank for a median of 13.6 years.
  • Utilized Cox models to evaluate the impact of green, blue spaces, and natural environment on AD and MCI risk.
  • Explored mediation effects by air pollutants and gene-environment interactions.
  • Identified 3513 incident cases of AD and 864 cases of MCI during the follow-up.
  • Higher green space, blue space, and natural environments within 300 m lower AD risk by 5.8%, 0.8%, and 5.7% respectively.
  • MCI risk showed reductions of 14.9-22.2% due to green and natural spaces, while blue space association with MCI was non-significant.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe716f82f25be989baachttps://doi.org/10.1080/13607863.2026.2678989
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Also Consider

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