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January 1, 2026NanoscaleOpen Access

Multiscale Porous Carbonate Apatite Honeycomb Granules Derived from a Metastable Calcium Carbonate Precursor for Enhanced Bone Formation

Koichiro Hayashi Ryo Kishida Kunio Ishikawa

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Key Points

This research aims to investigate the influence of multiscale porous honeycomb granules on bone regeneration.
Developed multiscale carbonate apatite granules from a calcium carbonate precursor.
Examined the pore architecture's effect on bone formation in vitro and in vivo.
Assessed biomechanical properties related to bone integration.
Honeycomb granules increased new bone formation by 30% compared to standard substitutes (p<0.05).
Improved mechanical stability observed with granule application, yielding higher load-bearing capacity.
Radiographic analysis indicated enhanced osteointegration at follow-up (p<0.01).

Implication

Evaluates bone formation using synthetic granules in aging populations, suggesting improved outcomes.

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Cite This Study

Hayashi et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe9f6f82f25be989bc99 https://doi.org/10.1039/d6nr01077f

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Micropore Size Distribution in Carbonate Apatite Honeycomb Granules on Bone ReplacementOriginal Research · 2026 · 2 citations
2Unidirectional Porous Carbonate Apatite Fabricated by Gelatin-Based Freeze Casting for Bone Regeneration.Original Research · 2026
3Lamellar Septa-like Structured Carbonate Apatite Scaffolds with Layer-by-Layer Fracture Behavior for Bone Regeneration2024 · 2 citations
4Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction2024 · 8 citations
5Highly Porous Carbonate Apatite Scaffolds Fabricated via Freeze‐Drying for Accelerated Bone ReplacementOriginal Research · 2026