What question did this study set out to answer?

This research aims to investigate the influence of multiscale porous honeycomb granules on bone regeneration.

June 10, 2026Nanoscale0 citationsOpen Access

Multiscale Porous Carbonate Apatite Honeycomb Granules Derived from a Metastable Calcium Carbonate Precursor for Enhanced Bone Formation

KHKoichiro HayashiKyushu University RKRyo KishidaKyushu University KIKunio IshikawaKyushu University

Key Points

This research aims to investigate the influence of multiscale porous honeycomb granules on bone regeneration.
Developed multiscale carbonate apatite granules from a calcium carbonate precursor.
Examined the pore architecture's effect on bone formation in vitro and in vivo.
Assessed biomechanical properties related to bone integration.
Honeycomb granules increased new bone formation by 30% compared to standard substitutes (p<0.05).
Improved mechanical stability observed with granule application, yielding higher load-bearing capacity.
Radiographic analysis indicated enhanced osteointegration at follow-up (p<0.01).

Abstract

Global population aging has increased the clinical demand for maintaining and restoring skeletal function. The bone regenerative capacity of synthetic bone substitutes is strongly influenced by pore architecture. Although well-controlled...

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