PCN-224-Pt Nanozyme for Dual-Mode Detection of Acetylcholinesterase via LMB-PEG

Weiyi Bai; Ling Teng; Xingzhi Yu; Qing Li; Huiing Tan; Yongchao Yao; Shufen Li; Limei Zhang; Hao Bai; Imran Shakir; Weihua Zhuang; Yuan Yang; Xuping Sun; Wenchuang Walter Hu

doi:10.1039/d6cc02043g

January 1, 2026Chemical Communications

PCN-224-Pt Nanozyme for Dual-Mode Detection of Acetylcholinesterase via LMB-PEG

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Key Points

The research aims to develop a novel detection platform for acetylcholinesterase relevant to Alzheimer's disease.
Developed a dual-mode detection platform using PCN-224-Pt nanozyme and LMB-PEG
Utilized colorimetric and fluorescent techniques for detection
Evaluated the system's performance in detecting acetylcholinesterase levels
Successfully detected acetylcholinesterase with improved sensitivity and specificity
Demonstrated a clear colorimetric change in the presence of the enzyme
Achieved significant amplification of fluorescent signals with the new platform

Implication

Demonstrates dual-mode detection of acetylcholinesterase in Alzheimer's disease, indicating a new diagnostic approach.

Abstract

Alzheimer's disease (AD) is closely associated with cholinergic dysfunction, with acetylcholinesterase (AChE) as a key biomarker. Here, a dual-mode colorimetric/fluorescent platform based on PCN-224-Pt nanozyme and LMB-PEG is developed, enabling...

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Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/6a28fecb6f82f25be989bea5 https://doi.org/10.1039/d6cc02043g

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PCN-224-Pt Nanozyme for Dual-Mode Detection of Acetylcholinesterase via LMB-PEG

Key Points

Implication

Abstract

Discussion

Cite This Study

PCN-224-Pt Nanozyme for Dual-Mode Detection of Acetylcholinesterase via LMB-PEG

Key Points

Implication

Abstract

Discussion

Cite This Study

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