Metal-Free Three Component Domino Synthesis of α, β-Unsaturated γ Lactams via Intramolecular Wittig Reaction

Developing novel and simple methods for α, β unsaturated γ-lactams is of prime importance for discovering new antibiotics through late stage modification of lactams. Herein, we report an easily adaptable procedure for the preparation of α, β unsaturated γ-lactams from easily available and economical starting materials. Most of the literature methods employed transition metal to construct γ-lactam ring, whereas the present method operates under metal free condition. The reaction involves sequential alkylation and acylation of amine, in-situ generation of phosphorus ylide, followed by intramolecular Wittig reaction.