Preparation of α,β,γ,γ-Tetrasubstituted α,β-Unsaturated γ-Lactams via Tandem or One-Pot Oxidative Ritter Reaction/Knoevenagel Condensation

Q: What type of study is this?

This is a Experimental Study study.

Yuting Chen; Yue‐Hong Hu; Zhang‐Yan Gan; Chengcheng Yu; J. Mo; Meng-En Chen; Xiao‐Ming Zhang; Fu‐Min Zhang

doi:10.1039/d5ob01300c

January 1, 2025Organic & Biomolecular Chemistry

Preparation of α,β,γ,γ-Tetrasubstituted α,β-Unsaturated γ-Lactams via Tandem or One-Pot Oxidative Ritter Reaction/Knoevenagel Condensation

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Key Points

An efficient synthesis of α,β,γ,γ-tetrasubstituted α,β-unsaturated γ-lactams was achieved through a new method.
The method combines the oxidative Ritter reaction and Knoevenagel condensation, improving overall reaction efficiency.
This study introduces the use of functionalized nitriles and 2-arylketone in a tandem process for the first time.
This approach indicates potential advancements in the synthesis of complex organic compounds.

Implication

One-pot synthesis shows potential for α,β-unsaturated γ-lactams from functionalized nitriles, implying advancements in organic synthesis.

Abstract

An efficient synthesis of α,β,γ,γ-tetrasubstituted α,β-unsaturated γ-lactams has been developed through a tandem or one-pot oxidative Ritter reaction/Knoevenagel condensation of the functionalized nitriles and 2-arylketone for the first time.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc49936b https://doi.org/10.1039/d5ob01300c

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Preparation of α,β,γ,γ-Tetrasubstituted α,β-Unsaturated γ-Lactams via Tandem or One-Pot Oxidative Ritter Reaction/Knoevenagel Condensation

Key Points

Implication

Abstract

Discussion

Cite This Study

Preparation of α,β,γ,γ-Tetrasubstituted α,β-Unsaturated γ-Lactams via Tandem or One-Pot Oxidative Ritter Reaction/Knoevenagel Condensation

Key Points

Implication

Abstract

Discussion

Cite This Study

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