Celecoxib-Loaded “Nano-in-Nano” Hierarchical Delivery System: Structure-Driven Synergistic Optimization of Diffusion Efficiency and Mechanical Stability for Osteoarthritis Therapy

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This research aims to develop a novel drug delivery system that enhances therapeutic efficacy in osteoarthritis by integrating sustained drug release and mechanical support.
Celecoxib-loaded PLGA nanoparticles were prepared via emulsion solvent evaporation.
The delivery system was fabricated using an electrospun nanofiber membrane and a genipin-crosslinked gelatin layer.
Characterization included assessments of particle size, mechanical properties, swelling behavior, and in vivo therapeutic potential in a rat model.
CXB-NPs exhibited an average particle size of 138.4 nm and a zeta potential of -58.74 mV, ensuring stability.
The NiN-HDS showed high porosity (87.16%) and sustained CXB release (67.16% cumulative release over 7 days).
In vivo testing demonstrated reduced cartilage damage and lower IL-1β and MMP-13 expression in the treated group.

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Evaluates the effectiveness of a celecoxib delivery system in osteoarthritis, suggesting improved therapeutic outcomes.

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Yang et al. (2026) studied this question.

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