Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 10, 2026Scientific ReportsOpen Access

The genetic etiology of spontaneous abortion: insights from chromosomal microarray analysis and whole-exome sequencing

View Full Paper
Ask AI
Bookmark
Share

Authors

LWLixia WangXinjiang Medical UniversityPLPei LiuXinjiang Medical UniversityWHWeibo HuangShihezi University

Discussion

Loading...

Member takes

Overview

Randomized trial identifies genetic factors in spontaneous abortion, suggesting improvements for diagnosis and understanding.

Key Points

  • The research aims to understand the genetic factors contributing to spontaneous abortion and improve diagnostic methods.
  • Collected embryonic tissue samples from 1585 patients with spontaneous abortion between January 2019 and June 2025.
  • Performed chromosomal microarray analysis and whole-exome sequencing on selected cases with negative results.
  • Conducted statistical analyses using chi-square tests, restricted cubic splines, and multivariate logistic regression.
  • Detected chromosomal abnormalities in 54.44% of cases, with trisomy 16 and X monosomy being the most common.
  • Identified a significant variant in the MOS gene linked to oocyte maturation defects and other clinically significant variants.
  • Revealed that maternal age ≥ 35 years is a risk factor (OR = 1.72, 95% CI: 1.31–2.26), while gestational age ≥ 12 weeks is protective (OR = 0.27, 95% CI: 0.21–0.34).

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a28fecb6f82f25be989bfd7https://doi.org/10.1038/s41598-026-53777-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application of Chromosomal Microarray Analysis in Genetic Reasons of Miscarriage Tissues2024 · 3 citations
  2. 2Clinical utility of chromosomal microarray and whole exome sequencing in evaluating genetic causes for pregnancy loss using products of conception specimens2025
  3. 3Clinical utility of chromosomal microarray analysis for genetic diagnosis in 708 cases of spontaneous abortion tissues2026
  4. 4Genetic Evaluation of Early Pregnancy Loss by Chromosomal Microarray Analysis: A Retrospective Analysis2025
  5. 5Evaluating the link between chromosomal abnormalities and diminished ovarian reserve, mode of conception, and history of prior miscarriages in cases of early missed abortion using CNV-seq2024