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June 10, 2026Cancer BiomarkersOpen Access

Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair–related genes with oral cancer

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Authors

JWJingbo WangWTWeiqing TangWDWeilong Ding

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Overview

Randomized trial identifies key DNA repair genes affecting oral cancer risk, suggesting targets for early detection and therapy.

Key Points

  • The study aims to uncover causal relationships between DNA repair-related genes and the risk of oral cancer (OCC).
  • Integrated summary data-based Mendelian randomization (SMR) analysis using GWAS, mQTL, eQTL, and pQTL data.
  • Conducted colocalization analysis to identify shared genetic variants.
  • Validated findings in the FinnGen_OCC cohort.
  • Identified 160 methylation sites linked to OCC, including 96 associated genes.
  • Confirmed 96 mQTLs, 20 eQTLs, and 2 pQTLs, with VHL, TP73, and JMJD1C as significant genes.
  • Functional validation showed VHL as the most consistent risk gene with P < 0.01 significance.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff6a6f82f25be989c4e0https://doi.org/10.1177/18758592261455209
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